23/01/12: Upcoming Agilent Webinar on “Array CGH and Genomic Medicine in Hematological Malignancies,” Feb. 9th
January 23, 2012 by Peter
This looks like an interesting event, because it covers the subject of using aCGH microarrays for cancer in a clinical setting.
The webinar will be run on WebEx and you can learn more/register here.
Event Description
Traditional cytogenetic techniques such as chromosome analysis and FISH have provided valuable genetic information for the evaluation of hematological malignancies. However, many genomic abnormalities remain undetected due to the limitations intrinsic to these techniques. Recently, the introduction of DNA array-based technologies has enabled the identification of previously undetected copy number changes with an increased resolution and sensitivity and a more precise determination of genomic break points and gene content. We have designed and validated a combined targeted-whole genome custom oligonucleotide microarray for the evaluation of hematological malignancies in clinical research. The use of this technology not only allowed us to confirm genetic alterations identified by chromosome analysis or FISH, but also enabled the detection of novel genomic imbalances in myeloid, lymphoid and plasma cell disorders. Several copy number alterations were observed in karyotypically normal patients allowing the discovery of potential tumor suppressor genes or oncogenes important in the pathogenesis of several hematological neoplasms such as myelodysplastic syndrome, multiple myeloma and chronic lymphocytic lymphoma. Our work also emphasizes the importance of incorporating this technology into current algorithms used in clinical cancer research.
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