The Human DNA Methylation Array is now available from Agilent. An update of the existing product, this array offers a more comprehensive set of DNA methylation regions. Features of note are:
• Expanded content: Includes >5000 “UMR regions” and expanded CpG Island content for increased coverage of methylated DNA regions
• Updated probe content: Offers more comprehensive coverage than previous CpG Island array design
More on the design:
The Agilent Human DNA Methylation Microarray is designed to interrogate known CpG islands and two additional groups of methylated DNA. The array is specifically designed for analysis of methylated DNA derived from affinity-based isolation methods such as methylated DNA immunoprecipitation (MDIP). The array is fully compatible with Agilent’s Genomics Workbench DNA Methylation module for analysis.
The array includes probes to study known CpG Islands and also includes additional probe content spanning 85 nucleotides proximal to each CpG island. This expanded coverage addresses recent findings suggesting that regions directly adjacent to canonical CpG islands can also exhibit differential methylation1. Coverage was also extended to tile ~5000 additional intervals identified as Undermethylated Regions (UMRs) in a recent joint publication between the laboratories of Howard Cedar and Agilent Technologies. This additional content is provided for a more comprehensive analysis of genome-wide DNA methylation