20% Diethylamine in Acetonitrile

This ready-to-use solution of 20% diethylamine in acetonitrile (v/v) is specifically formulated for the removal of cyanoethyl (CE) protecting groups from phosphate backbones in solid-phase oligonucleotide synthesis.

• Composition: 20% diethylamine in acetonitrile (v/v)
• Function: Elimination of CE protecting groups via β-elimination
• Application: Post-synthesis deprotection of oligonucleotides
• Instrument Compatibility: Suitable for both manual and automated synthesis workflows

The formulation’s low water content ensures clean and reproducible CE removal, reducing the risk of side reactions and preserving oligo integrity — especially critical for sensitive or large-scale synthesis.